BTTAA( —— )

Catalog No. M11329 CAS No. 1334179-85-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

BTTAA
Note

Research use only, not for human use.
Brief Description

A Cu(I)-stabilizing ligand that shows high activity in accelerating the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC); BTTAA-Cu(I) catalyst is the optimal choice for cell surface azide-alkyne ligation, mediates CuAAC and copper-free click chemistry.
Description

A Cu(I)-stabilizing ligand that shows high activity in accelerating the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC); BTTAA-Cu(I) catalyst is the optimal choice for cell surface azide-alkyne ligation, mediates CuAAC and copper-free click chemistry.
In Vitro

BTTAAis a Cu(I)-stabilizing ligand. Using the Glu18AzF mutant of ubiquitin as a model system with C3-Tm3+ and C4-Tm3+, Cu-BTTAA performs significantly better as a catalyst than Cu-THPTA or Cu-TBTA. BTTAA proves to perform much better than THPTA (tris[(1-hydroxy-propyl-1H-1,2,3-triazol-4-yl)methyl]amine) or TBTA (tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine).
In Vivo

——
Synonyms

——
Pathway

Antibody Drug Conjugates (ADC)
Target

ADCs Linker/Click Chemistry
Recptor

ADCs Linker/Click Chemistry
Research Area

Other Indications
Indication

——

CAS Number

1334179-85-9
Formula Weight

430.5073
Molecular Formula

C19H30N10O2
Purity

>98% (HPLC)
Solubility

H2O: ≥ 34 mg/mL
SMILES

CC(C)(C)N1C=C(N=N1)CN(CC2=CN(N=N2)CC(=O)O)CC3=CN(N=N3)C(C)(C)C
Chemical Name

1H-1,2,3-Triazole-1-acetic acid, 4-[[bis[[1-(1,1-dimethylethyl)-1H-1,2,3-triazol-4-yl]methyl]amino]methyl]-

1. Loh CT, et al. Bioconjug Chem. 2013 Feb 20;24(2):260-8. 2. Besanceney-Webler C, et al. Angew Chem Int Ed Engl. 2011 Aug 22;50(35):8051-6.

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