Imigliptin dihydrochloride( Imigliptin )

Catalog No. M11272 CAS No. 1314944-07-4

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Product Name

Imigliptin dihydrochloride
Note

Research use only, not for human use.
Brief Description

A novel potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM.
Description

A novel potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM; displays no activity against DPP-8 and DPP-9 (IC50>100 uM); shows strong effects on db/db mice in lowing glucose level, reducing AUC of oral glucose tolerance, decreasing TG and HbA1c levels, and protecting beta-cell.Diabetes Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

Imigliptin
Pathway

Metabolic Enzyme/Protease
Target

DPP
Recptor

DPP
Research Area

Metabolic Disease
Indication

Diabetes

CAS Number

1314944-07-4
Formula Weight

449.38
Molecular Formula

C21H26Cl2N6O
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

N#CC1=CC=CC=C1CN(C2=C(N3C[C@H](N)CCC3)C=C(C)N=C2N4C)C4=O.[H]Cl.[H]Cl
Chemical Name

(R)-2-((7-(3-aminopiperidin-1-yl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)methyl)benzonitrile dihydrochloride

1. Shu C, et al. ACS Med Chem Lett. 2014 Jun 16;5(8):921-6. 2. Liu D, et al. Eur J Pharm Sci. 2016 Jun 30;89:73-82.

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