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Radalbuvir

CAS No. 1314795-11-3

Radalbuvir( GS 9669 )

Catalog No. M11266 CAS No. 1314795-11-3

Radalbuvir (GS-9669) is a highly optimized thumb site II nonnucleoside inhibitor of HCV NS5B polymerase with binding affinity of 1.35 nM for genotype 1b.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Radalbuvir
  • Note
    Research use only, not for human use.
  • Brief Description
    Radalbuvir (GS-9669) is a highly optimized thumb site II nonnucleoside inhibitor of HCV NS5B polymerase with binding affinity of 1.35 nM for genotype 1b.
  • Description
    Radalbuvir (GS-9669) is a highly optimized thumb site II nonnucleoside inhibitor of HCV NS5B polymerase with binding affinity of 1.35 nM for genotype 1b; shows inhibition of WT genotype 1b replicon and NS5B M423T mutant replicon with EC50 of 6 nM and 12 nM respectively.
  • In Vitro
    Radalbuvir (GS-9669) shows high in vitro metabolic stability, long residence time in rats, and maintained high activity against the NS5B M423T mutation (GT1b M423T EC50 = 14 nM).
  • In Vivo
    ——
  • Synonyms
    GS 9669
  • Pathway
    Microbiology/Virology
  • Target
    HCV
  • Recptor
    HCV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1314795-11-3
  • Formula Weight
    543.719
  • Molecular Formula
    C30H41NO6S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=CCC(CC1)C(=O)N(C2CCC(CC2)(COC3CCOC3)O)C4=C(SC(=C4)C#CC(C)(C)C)C(=O)O
  • Chemical Name
    2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-((cis-4-hydroxy-4-((((3S)-tetrahydro-3-furanyl)oxy)methyl)cyclohexyl)(((1R)-4-methyl-3-cyclohexen-1-yl)carbonyl)amino)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lazerwith SE, et al. J Med Chem. 2014 Mar 13;57(5):1893-901. 2. Fenaux M, et al. Antimicrob Agents Chemother. 2013 Feb;57(2):804-10. 3. Dvory-Sobol H, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6599-606.
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