INCB10820( PF-4178903 | INCB 10820 )

Catalog No. M11249 CAS No. 1310796-72-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

INCB10820
Note

Research use only, not for human use.
Brief Description

INCB10820 (PF-4178903) is a potent, selective, orally bioavailable dual CCR2 and CCR5 antagonist with binding IC50 of 3.0 nM and 5.3 nM, respectively.
Description

INCB10820 (PF-4178903) is a potent, selective, orally bioavailable dual CCR2 and CCR5 antagonist with binding IC50 of 3.0 nM and 5.3 nM, respectively; displays an IC50 of 4.3 nM in CCR5 chemotaxis functional assay; is active against mouse, rat and cynomolgus monkey CCR2 with binding IC50 of 2.8, 2.9 and 4.6 nM, respectively, but inactive against canine CCR2, also is active against mouse and cynomolgus monkey CCR5 with IC50 of 71 and 4.0 nM, respectively.
In Vitro

——
In Vivo

——
Synonyms

PF-4178903 | INCB 10820
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

——
Indication

——

CAS Number

1310796-72-5
Formula Weight

498.591
Molecular Formula

C25H37F3N4O3
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

(3S,4S)-N-[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}carbonyl)cyclopentyl]-3-methoxytetrahydro-2H-pyran-4-amine

1. Zheng C, et al. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1442-6.

Calculator

molnova catalog