RO-5508887( RO 5508887 | RO5508887 | RG-7129 | RG7129 )

Catalog No. M11242 CAS No. 1310347-50-2

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Product Name

RO-5508887
Note

Research use only, not for human use.
Brief Description

A potent, selective BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM) .
Description

A potent, selective BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM) but >1,000-fold selectivity over cathepsin D, cathepsin E, pepsin and renin; has IC50 of 18 nM in HEK293APP cells and in neuronal cultures derived from human neuronal stem cells; significantly enhances antiamyloid effect combined with gantenerumab.Alzheimer Disease Phase 1 Clinical.
In Vitro

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In Vivo

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Synonyms

RO 5508887 | RO5508887 | RG-7129 | RG7129
Pathway

Metabolic Enzyme/Protease
Target

BACE
Recptor

BACE
Research Area

Neurological Disease
Indication

Alzheimer Disease

CAS Number

1310347-50-2
Formula Weight

389.338
Molecular Formula

C18H14F3N5O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 85 mg/mL (218.32 mM)
SMILES

CC1(C(COC(=N1)N)(F)F)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)C#N)F
Chemical Name

5-Cyano-pyridine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluorophenyl]amide

1. Jacobsen H, et al. J Neurosci. 2014 Aug 27;34(35):11621-30.

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