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TROX-1
CAS No. 1309601-26-0
TROX-1( TROX 1 | TROX1 )
Catalog No. M11237 CAS No. 1309601-26-0
A potent, state-dependent blocker of Cav2 channels that preferentially inhibits potassium-triggered calcium influx through recombinant Cav2.2 under depolarized conditions with IC50 of 0.27 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1053 | Get Quote |
|
| 50MG | 2142 | Get Quote |
|
| 100MG | 2790 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameTROX-1
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, state-dependent blocker of Cav2 channels that preferentially inhibits potassium-triggered calcium influx through recombinant Cav2.2 under depolarized conditions with IC50 of 0.27 uM.
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DescriptionA potent, state-dependent blocker of Cav2 channels that preferentially inhibits potassium-triggered calcium influx through recombinant Cav2.2 under depolarized conditions with IC50 of 0.27 uM, compared with hyperpolarized conditions (IC50>20 uM); inhibits omiga-conotoxin GVIA-sensitive calcium currents with greater potency under depolarized conditions (IC50=0.4 uM) in rat DRG neurons, blocks all Ca(v)2 family channels. reduces nociception in preclinical pain models, while sparing normal cardiac and behavioral functions.
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In Vitro——
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In Vivo——
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SynonymsTROX 1 | TROX1
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorCalcium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number1309601-26-0
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Formula Weight434.859
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Molecular FormulaC22H16ClFN6O
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1N(C2=NNC=N2)C3=C(C=C(C4=CC=C(F)C(Cl)=C4)C=C3)[C@@]1(C)CC5=CN=CN=C5
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Chemical Name(3R)-5-(3-chloro-4-fluorophenyl)-3-methyl-3-(pyrimidin-5-ylmethyl)-1-(1H-1,2,4-triazol-3-yl)-1,3-dihydro-2H-indol-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Abbadie C, et al. J Pharmacol Exp Ther. 2010 Aug;334(2):545-55.
2. Swensen AM, et al. Mol Pharmacol. 2012 Mar;81(3):488-97.
3. Patel R, et al. Neuroscience. 2015 Jun 25;297:47-57.
4. Rahman W, et al. Neuroscience. 2015 Oct 1;305:76-85.
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