Dorzolamide hydrochloride( L-671,152 | MK-507 )

Catalog No. M11227 CAS No. 130693-82-2

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HNMR

HPLC

MSDS

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Product Name

Dorzolamide hydrochloride
Note

Research use only, not for human use.
Brief Description

Dorzolamide Hcl(L671152 Hcl; MK507 Hcl) is an anti-glaucoma agent, which is a carbonic anhydrase inhibitor.
Description

Dorzolamide Hcl(L671152 Hcl; MK507 Hcl) is an anti-glaucoma agent, which is a carbonic anhydrase inhibitor.(In Vitro):Component A, caused by an inward flux of CO2 and its subsequent hydration by CA-II, is blocked by Dorzolamide in a dose-dependent manner with an 50% inhibitory concentration IC50 of 2.4 μM (95% confidence interval: 0.5-10.85 μM).(In Vivo):Dorzolamide (3, 10, or 30 mg/kg/day, ip) synergized mitomycin C exhibits anti-tumor activity in EAC solid tumor models. Dorzolamide produces a dose-dependent decrease in the calculated ratio (relative value of 57.3±1, 25.5±1.8, and 24.3± 0.7 %, respectively).
In Vitro

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In Vivo

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Synonyms

L-671,152 | MK-507
Pathway

Membrane Transporter/Ion Channel
Target

Carbonic Anhydrase
Recptor

Carbonic anhydrase I| Carbonic anhydrase II| Carbonic anhydrase IV
Research Area

Other Indications
Indication

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CAS Number

130693-82-2
Formula Weight

360.9
Molecular Formula

C10H17ClN2O4S3
Purity

>98% (HPLC)
Solubility

Water: 14 mg/mL (38.79 mM)
SMILES

O=S(C(S1)=CC([C@@H](NCC)C[C@@H]2C)=C1S2(=O)=O)(N)=O.[H]Cl
Chemical Name

(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride

1.Maren TH, et al. J Ocul Pharmacol Ther, 1997, 13(1), 23-30.

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