BAY 1024767( BAY1024767 )

Catalog No. M11142 CAS No. 1273068-71-5

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HNMR

HPLC

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Product Name

BAY 1024767
Note

Research use only, not for human use.
Brief Description

BAY 1024767 (BAY1024767) is a higly potent antagonist of androgen receptor (AR) wild-type (IC50=46 nM) and mutant forms located in the AR ligand-binding domain (LBD).
Description

BAY 1024767 (BAY1024767) is a higly potent antagonist of androgen receptor (AR) wild-type (IC50=46 nM) and mutant forms located in the AR ligand-binding domain (LBD); inhibits mutants L701H, E709Y, V715M, W741C, H874Y (IC50=31 nM), F876L, T877A, M895T and M895V (IC50=11 nM); promotes nuclear localization of AR wild-type and mutants in the absence of R1881 in COS-7 cells; demonstrates KuCaP-1 prostate cancer model which bears the W741C bicalutamide resistance mutation and in the syngeneic prostate cancer rat model Dunning R3327-G.
In Vitro

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In Vivo

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Synonyms

BAY1024767
Pathway

Endocrinology/Hormones
Target

Androgen Receptor (AR)
Recptor

Androgen Receptor (AR)
Research Area

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Indication

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CAS Number

1273068-71-5
Formula Weight

492.517
Molecular Formula

C23H23F3N4O3S
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

4-(3-((6-(2-hydroxy-2-methylpropoxy)pyridin-3-yl)methyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

1. Sugawara T, et al. Oncotarget. 2016 Feb 2;7(5):6015-28.

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