Paromomycin Sulfate( —— )

Catalog No. M11105 CAS No. 1263-89-4

Paromomycin Sulfate is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.

Purity : >98% (HPLC)

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Biological Information

Product Name

Paromomycin Sulfate
Note

Research use only, not for human use.
Brief Description

Paromomycin Sulfate is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.
Description

Paromomycin Sulfate is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.(In Vitro):Paromomycin sulfate (500 μg/ml) reduces intracellular parasitic forms by 97.2% compared to control in Caco-2 cells and reduces the percentage of intracellular C. parvum forms by 99.5% in HCT-8 cells.(In Vivo):Paromomycin sulfate (oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infection) reduces the number of oocyst per gram of feces and intestine. It shows minimal focal inflammation in only 20% of the sections at 50 mg/kg from the intestines of mice infected with C. parvum and only 10% of focal inflammation at 200 mg/kg.
In Vitro

Paromomycin sulfate (500 μg/ml) reduces intracellular parasitic forms by 97.2% compared to control in Caco-2 cells and reduces the percentage of intracellular C. parvum forms by 99.5% in HCT-8 cells.
In Vivo

Paromomycin sulfate (oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infection) reduces the number of oocyst per gram of feces and intestine. It shows minimal focal inflammation in only 20% of the sections at 50 mg/kg from the intestines of mice infected with C. parvum and only 10% of focal inflammation at 200 mg/kg. Animal Model:Male Swiss albino miceDosage:50 mg/kg-200 mg/kg Administration:Oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infectionResult:Was against cryptosporidiosis in vivo.
Synonyms

——
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

16S rRNA
Research Area

Infection
Indication

——

Chemical Information

CAS Number

1263-89-4
Formula Weight

713.71
Molecular Formula

C23H47N5O18S
Purity

>98% (HPLC)
Solubility

Water: 100 mg/mL (140.11 mM)
SMILES

C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Davidson RN, et al. ParomomycinTrans R Soc Trop Med Hyg, 2009, 103(7), 653-660.

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