NMS-P118( NMS-P118 | NMS-P 118 | NMS P118 )

Catalog No. M11093 CAS No. 1262417-51-5

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Datasheet

HNMR

HPLC

MSDS

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Product Name

NMS-P118
Note

Research use only, not for human use.
Brief Description

A potent and highly selective PARP-1 inhibitor with Kd of 9 nM; shows 150-fold selectivity for PARP-1 over PARP-2.
Description

A potent and highly selective PARP-1 inhibitor with Kd of 9 nM; shows 150-fold selectivity for PARP-1 over PARP-2; exhibits excellent ADME and pharmacokinetic profiles and high efficacy in MDA-MB-436 and Capan-1 xenograft models; orally available.Breast Cancer Preclinical.
In Vitro

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In Vivo

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Synonyms

NMS-P118 | NMS-P 118 | NMS P118
Pathway

Cell Cycle/DNA Damage
Target

PARP
Recptor

PARP
Research Area

Cancer
Indication

Breast Cancer

CAS Number

1262417-51-5
Formula Weight

395.4187
Molecular Formula

C20H24F3N3O2
Purity

>98% (HPLC)
Solubility

DMSO: 16 mg/mL
SMILES

O=C(C1=CC(F)=CC(CN2C3CCN(C4CCC(F)(F)CC4)CC3)=C1C2=O)N
Chemical Name

1H-Isoindole-4-carboxamide, 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-

1. Papeo G, et al. J Med Chem. 2015 Sep 10;58(17):6875-98.

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