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NMS-P118
CAS No. 1262417-51-5
NMS-P118( NMS-P118 | NMS-P 118 | NMS P118 )
Catalog No. M11093 CAS No. 1262417-51-5
A potent and highly selective PARP-1 inhibitor with Kd of 9 nM; shows 150-fold selectivity for PARP-1 over PARP-2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 60 | Get Quote |
|
| 5MG | 105 | Get Quote |
|
| 10MG | 177 | Get Quote |
|
| 25MG | 357 | Get Quote |
|
| 50MG | 537 | Get Quote |
|
| 100MG | 781 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameNMS-P118
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and highly selective PARP-1 inhibitor with Kd of 9 nM; shows 150-fold selectivity for PARP-1 over PARP-2.
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DescriptionA potent and highly selective PARP-1 inhibitor with Kd of 9 nM; shows 150-fold selectivity for PARP-1 over PARP-2; exhibits excellent ADME and pharmacokinetic profiles and high efficacy in MDA-MB-436 and Capan-1 xenograft models; orally available.Breast Cancer Preclinical.
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In Vitro——
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In Vivo——
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SynonymsNMS-P118 | NMS-P 118 | NMS P118
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PathwayCell Cycle/DNA Damage
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TargetPARP
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RecptorPARP
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number1262417-51-5
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Formula Weight395.4187
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Molecular FormulaC20H24F3N3O2
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Purity>98% (HPLC)
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SolubilityDMSO: 16 mg/mL
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SMILESO=C(C1=CC(F)=CC(CN2C3CCN(C4CCC(F)(F)CC4)CC3)=C1C2=O)N
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Chemical Name1H-Isoindole-4-carboxamide, 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Papeo G, et al. J Med Chem. 2015 Sep 10;58(17):6875-98.
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