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CEP-33779
CAS No. 1257704-57-6
CEP-33779( CEP33779 | CEP-33779 | CEP 33779. )
Catalog No. M11060 CAS No. 1257704-57-6
CEP-33779 is a novel, selective, and orally bioavailable inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 2MG | 51 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 140 | In Stock |
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| 25MG | 244 | In Stock |
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| 50MG | 368 | In Stock |
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| 100MG | 548 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 1190 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCEP-33779
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NoteResearch use only, not for human use.
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Brief DescriptionCEP-33779 is a novel, selective, and orally bioavailable inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.
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DescriptionCEP-33779 is a novel, selective, and orally bioavailable inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.
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In Vitro——
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In Vivo——
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SynonymsCEP33779 | CEP-33779 | CEP 33779.
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PathwayAngiogenesis
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TargetJAK
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RecptorJAK2,JAK3
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1257704-57-6
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Formula Weight462.57
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Molecular FormulaC24H26N6O2S
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Purity>98% (HPLC)
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SolubilityDMSO:93 mg/mL (201.05 mM); Ethanol:<1 mg/mL (<1 mM); Water：<1 mg/mL (<1 mM)
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SMILESO=S(C1=CC=C(C2=CC=CN3C2=NC(NC4=CC=CC(N5CCN(C)CC5)=C4)=N3)C=C1)(C)=O
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Chemical NameN-(3-(4-methylpiperazin-1-yl)phenyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dugan BJ, et al. A selective, orally bioavailable 1,2,4-triazolo1,5-apyridine-based inhibitor of Janus kinase 2 for use in anticancer therapy: discovery of CEP-33779. J Med Chem. 2012 Jun 14;55(11):5243-54.
2. Seavey MM, et al. Therapeutic efficacy of CEP-33779, a novel selective JAK2 inhibitor, in a mouse model of colitis-induced colorectal cancer. Mol Cancer Ther. 2012 Apr;11(4):984-93.
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