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Home - Products - GPCR/G Protein - Antibacterial - TBA-354

TBA-354

CAS No. 1257426-19-9

TBA-354( TBA354 )

Catalog No. M11059 CAS No. 1257426-19-9

TBA-354 is a novel antitubercular agent that shows MIC of 6 uM against M. tuberculosis H37Rv.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 28 In Stock
10MG 39 In Stock
25MG 74 In Stock
50MG 116 In Stock
100MG 187 In Stock
200MG 272 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    TBA-354
  • Note
    Research use only, not for human use.
  • Brief Description
    TBA-354 is a novel antitubercular agent that shows MIC of 6 uM against M. tuberculosis H37Rv.
  • Description
    TBA-354 is a novel antitubercular agent that shows MIC of 6 uM against M. tuberculosis H37Rv; maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates, demonstrates superior potency and pharmacokinetic profile compared with PA-824, 5 to 10 times more potent than PA-824.Bacterial Infection Phase 1 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TBA354
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Others
  • Research Area
    Infection
  • Indication
    Bacterial Infection

Chemical Information

  • CAS Number
    1257426-19-9
  • Formula Weight
    436.3414
  • Molecular Formula
    C19H15F3N4O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 46 mg/mL
  • SMILES
    O=[N+](C1=CN2C(OC[C@@H](OCC3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)N=C3)C2)=N1)[O-]
  • Chemical Name
    5H-Imidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[[6-[4-(trifluoromethoxy)phenyl]-3-pyridinyl]methoxy]-, (6S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kmentova I, et al. J Med Chem. 2010 Dec 9;53(23):8421-39. 2. Upton AM, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):136-44. 3. Tasneen R, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):129-35.
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