RVX2135( RVX 2135 )

Catalog No. M11020 CAS No. 1253733-17-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

RVX2135
Note

Research use only, not for human use.
Brief Description

RVX2135 is a novel potent and orally bioavailable inhibitor of Brd2, Brd3, Brd4, and BrdT.
Description

RVX2135 is a novel potent and orally bioavailable inhibitor of Brd2, Brd3, Brd4, and BrdT with IC50 of 1.31, 0.58, 0.44, and 1.58 uM, respectively; blocks proliferation of Myc-induced mouse lymphoma cells and induces Caspase-dependent apoptosis; exhibits broad transcriptional effects in Myc-transgenic lymphoma cells affecting many transcription factor networks.
In Vitro

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In Vivo

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Synonyms

RVX 2135
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

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Indication

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CAS Number

1253733-17-3
Formula Weight

411.502
Molecular Formula

C23H29N3O4
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1=C(OCCNC(C)C)C(C)=CC(C2=NC3=CC(OC)=CC(OC)=C3C(N2)=O)=C1
Chemical Name

2-(4-(2-(isopropylamino)ethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

1. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339. 2. Bhadury J, et al. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2721-30.

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