CP21R7( CP21 )

Catalog No. M11014 CAS No. 125314-13-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

CP21R7
Note

Research use only, not for human use.
Brief Description

A high-affinity, selective GSK3β inhibitor that activates canonical Wnt signaling.
Description

A high-affinity, selective GSK3β inhibitor that activates canonical Wnt signaling; promotes rapid and efficient differentiation of human pluripotent stem cells (hPSCs) into vascular endothelial and smooth muscle cells.(In Vitro):CP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC50 of 1.8 nM; the IC50 of CP21R7 against PKCα is 1900 nM. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm.
In Vitro

CP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC50 of 1.8 nM; the IC50 of CP21R7 against PKCα is 1900 nM. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm.
In Vivo

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Synonyms

CP21
Pathway

PI3K/Akt/mTOR signaling
Target

GSK-3
Recptor

GSK-3β
Research Area

Other Indications
Indication

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CAS Number

125314-13-8
Formula Weight

317.3413
Molecular Formula

C19H15N3O2
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 32 mg/mL
SMILES

O=C(C(C1=CC=CC(N)=C1)=C2C3=CN(C)C4=C3C=CC=C4)NC2=O
Chemical Name

1H-Pyrrole-2,5-dione, 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-

1. Patsch C, et al. Nat Cell Biol. 2015 Aug;17(8):994-1003. 2. Sahara M, et al. Cell Res. 2014 Jul;24(7):820-41.

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