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NC-005
CAS No. 1237540-74-7
NC-005( NC 005 | NC005 )
Catalog No. M10955 CAS No. 1237540-74-7
A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNC-005
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely.
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DescriptionA potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely; shows cytotoxicity against multiple myeloma cells with IC50 of 30 nM-1.5 uM.
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In Vitro——
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In Vivo——
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SynonymsNC 005 | NC005
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PathwayProteasome/Ubiquitin
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TargetProteasome
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RecptorProteasome
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Research Area——
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Indication——
Chemical Information
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CAS Number1237540-74-7
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Formula Weight663.815
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Molecular FormulaC40H45N3O6
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(S)-3-(4-methoxyphenyl)-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-(2-(naphthalen-2-yl)acetamido)propanamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Britton M, et al. Chem Biol. 2009 Dec 24;16(12):1278-89.
2. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209.
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