Azasetron hydrochloride( Azasetron hydrochloride | Y 25130 | Y-25130 | Y25130. )

Catalog No. M10908 CAS No. 123040-16-4

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Product Name

Azasetron hydrochloride
Note

Research use only, not for human use.
Brief Description

Azasetron Hydrochloride is a 5-HT3 receptor antagonist which is used as an anti-emetic.
Description

Azasetron Hydrochloride is a 5-HT3 receptor antagonist which is used as an anti-emetic.Azasetron inhibited the specific binding of [3H]quipazine to 5-HT3 receptors at the synaptic membranes of the rat cerebral cortex.(In Vivo):Azasetron could effectively penetrate through the skin and pass into the systemic circulation.
In Vitro

——
In Vivo

Azasetron could effectively penetrate through the skin and pass into the systemic circulation. Animal Model:Four male Bama miniature pigs weighing 9-11 kg (15-16 weeks old).Dosage:0.5 mg/kg.Administration:I.V. administration via the abdominal vein.Result:The mean plasma concentration dropped to minimum at 36 h. Cmax = 44.88 ± 7.16 ng/mL) was achieved at the time point of 66.00 ± 22.98 h (Tmax).
Synonyms

Azasetron hydrochloride | Y 25130 | Y-25130 | Y25130.
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT3
Research Area

Neurological Disease
Indication

——

CAS Number

123040-16-4
Formula Weight

386.27
Molecular Formula

C17H20ClN3O3·HCl
Purity

>98% (HPLC)
Solubility

Water: 3 mg/mL (7.76 mM)
SMILES

c1(cc(C(N[C@@H]2CN3CCC2CC3)=O)c2c(c1)N(C)C(=O)CO2)Cl.Cl
Chemical Name

2H-1,4-Benzoxazine-8-carboxamide, 3,4-dihydro-N-1-azabicyclo(2.2.2)oct-3-yl-6-chloro-4-methyl-3-oxo-, monohydrochloride

1.Katayama K, et al. Jpn J Pharmacol. 1997 Apr;73(4):357-60.

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