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AZD3839
CAS No. 1227163-84-9
AZD3839( AZD-3839 | AZD 3839 )
Catalog No. M10876 CAS No. 1227163-84-9
AZD3839 (AZD-3839, AZD 3839) is a potent and selective BACE1 inhibitor with Ki of 26 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 61 | Get Quote |
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| 5MG | 104 | Get Quote |
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| 10MG | 160 | Get Quote |
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| 25MG | 327 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameAZD3839
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NoteResearch use only, not for human use.
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Brief DescriptionAZD3839 (AZD-3839, AZD 3839) is a potent and selective BACE1 inhibitor with Ki of 26 nM.
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DescriptionAZD3839 (AZD-3839, AZD 3839) is a potent and selective BACE1 inhibitor with Ki of 26 nM, displays 14- and >1000-fold selectivity against BACE2 and cathepsin D; inhibits Aβ (Aβ40 IC50=4.8 nM) and sAPPβ release from modified and wild-type human SH-SY5Y cells and mouse N2A cells as well as from mouse and guinea pig primary cortical neurons; exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate; demonstrates significant reduction of β-amyloid peptides in mouse brain.Alzheimer Disease Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsAZD-3839 | AZD 3839
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PathwayMetabolic Enzyme/Protease
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TargetBACE
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RecptorBACE1
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number1227163-84-9
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Formula Weight431.4125
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Molecular FormulaC24H16F3N5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESNC1=N[C@@](C2=CC=CC(C3=CN=CN=C3)=C2)(C4=CC(C(F)F)=NC=C4)C5=C1C(F)=CC=C5
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Chemical Name1H-Isoindol-3-amine, 1-[2-(difluoromethyl)-4-pyridinyl]-4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-, (1S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Swahn BM, et al. J Med Chem. 2012 Nov 8;55(21):9346-61.
2. Jeppsson F, et al. J Biol Chem. 2012 Nov 30;287(49):41245-57.
3. Aasa J, et al. Drug Metab Dispos. 2013 Jan;41(1):159-69.
4. Sparve E, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):469-78.
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