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AMG-579
CAS No. 1227067-61-9
AMG-579( AMG 579 | AMG579 )
Catalog No. M10873 CAS No. 1227067-61-9
AMG-579 is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 71 | In Stock |
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| 2MG | 37 | In Stock |
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| 5MG | 64 | In Stock |
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| 10MG | 102 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAMG-579
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NoteResearch use only, not for human use.
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Brief DescriptionAMG-579 is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM.
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DescriptionAMG-579 is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM; displays high selectivity with IC50 > 30 uM against all other PDE isoforms; demonstrates excellent target occupancy efficacy in PCP-LMA behavioral model.Schizophrenia Phase 1 Clinical.
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In Vitro——
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In VivoAMG 579 shows statistically significant reduction of PCP induced behavior in rats over the 2 h period. Minimum effective doses for efficacy in PCP-LMA model is determined to be 0.3 mg/kg for AMG 579. In dog, 5 exhibits superior oral bioavailability of 72%.
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SynonymsAMG 579 | AMG579
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research AreaNeurological Disease
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IndicationSchizophrenia
Chemical Information
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CAS Number1227067-61-9
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Formula Weight441.491
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Molecular FormulaC25H23N5O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 41.67 mg/mL (94.39 mM)
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SMILESO=C(C1=CC=C(OC2=NC=CN=C2C3CCN(C(C)=O)CC3)C=C1)C4=NC5=CC=CC=C5N4
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Chemical Name1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hu E, et al. J Med Chem. 2014 Aug 14;57(15):6632-41.
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