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Home - Products - GPCR/G Protein - Antibacterial - G0507

G0507

CAS No. 1223998-29-5

G0507( G0507 )

Catalog No. M10857 CAS No. 1223998-29-5

G 0507 is a novel inhibitor of the bacterial LolCDE ABC transporter, binds to LolCDE and stimulates its ATPase activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    G0507
  • Note
    Research use only, not for human use.
  • Brief Description
    G 0507 is a novel inhibitor of the bacterial LolCDE ABC transporter, binds to LolCDE and stimulates its ATPase activity.
  • Description
    G 0507 is a novel inhibitor of the bacterial LolCDE ABC transporter, binds to LolCDE and stimulates its ATPase activity; results in accumulation of fully processed Lpp, an outer membrane lipoprotein, in the inner membrane in E. coli cells, still binds to LolCDE harboring a LolCQ258K mutation, which confers high-level resistance to G0507 in vivo, but no longer stimulates ATPase activity; a useful chemical probe to dissect lipoprotein trafficking in Gram-negative bacteria.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    G0507
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1223998-29-5
  • Formula Weight
    353.396
  • Molecular Formula
    C18H15N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 5 mg/mL (14.15 mM)
  • SMILES
    ——
  • Chemical Name
    5-(4-methoxyphenyl)-6-(5-methylthiophen-2-yl)-1,7-dihydro-2H-pyrrolo[2,3-d]pyrimidine-2,4(3H)-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nickerson NN, et al. Antimicrob Agents Chemother. 2018 Jan 16. pii: AAC.02151-17.
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