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G0507
CAS No. 1223998-29-5
G0507( G0507 )
Catalog No. M10857 CAS No. 1223998-29-5
G 0507 is a novel inhibitor of the bacterial LolCDE ABC transporter, binds to LolCDE and stimulates its ATPase activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 447 | Get Quote |
|
| 50MG | 1485 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameG0507
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NoteResearch use only, not for human use.
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Brief DescriptionG 0507 is a novel inhibitor of the bacterial LolCDE ABC transporter, binds to LolCDE and stimulates its ATPase activity.
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DescriptionG 0507 is a novel inhibitor of the bacterial LolCDE ABC transporter, binds to LolCDE and stimulates its ATPase activity; results in accumulation of fully processed Lpp, an outer membrane lipoprotein, in the inner membrane in E. coli cells, still binds to LolCDE harboring a LolCQ258K mutation, which confers high-level resistance to G0507 in vivo, but no longer stimulates ATPase activity; a useful chemical probe to dissect lipoprotein trafficking in Gram-negative bacteria.
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In Vitro——
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In Vivo——
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SynonymsG0507
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number1223998-29-5
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Formula Weight353.396
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Molecular FormulaC18H15N3O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (14.15 mM)
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SMILES——
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Chemical Name5-(4-methoxyphenyl)-6-(5-methylthiophen-2-yl)-1,7-dihydro-2H-pyrrolo[2,3-d]pyrimidine-2,4(3H)-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nickerson NN, et al. Antimicrob Agents Chemother. 2018 Jan 16. pii: AAC.02151-17.
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