G0507

Research use only, not for human use.

G 0507 is a novel inhibitor of the bacterial LolCDE ABC transporter, binds to LolCDE and stimulates its ATPase activity.

G 0507 is a novel inhibitor of the bacterial LolCDE ABC transporter, binds to LolCDE and stimulates its ATPase activity; results in accumulation of fully processed Lpp, an outer membrane lipoprotein, in the inner membrane in E. coli cells, still binds to LolCDE harboring a LolCQ258K mutation, which confers high-level resistance to G0507 in vivo, but no longer stimulates ATPase activity; a useful chemical probe to dissect lipoprotein trafficking in Gram-negative bacteria.

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G0507

GPCR/G Protein

Antibacterial

Antibacterial

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1223998-29-5

353.396

C18H15N3O3S

>98% (HPLC)

In Vitro:?DMSO : 5 mg/mL (14.15 mM)

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5-(4-methoxyphenyl)-6-(5-methylthiophen-2-yl)-1,7-dihydro-2H-pyrrolo[2,3-d]pyrimidine-2,4(3H)-dione

(-20℃)

With Ice Pack

≥ 2 years