Cart
sales@molnova.com
JW-7-25-1
CAS No. 1222998-57-3
JW-7-25-1( JW-7-25-1 | JW 7-25-1 | JW7-25-1 )
Catalog No. M10849 CAS No. 1222998-57-3
JW-7-25-1 is a potent MELK inhibitor with biochemical IC50 of 5.0 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 963 | Get Quote |
|
| 50MG | 1962 | Get Quote |
|
| 100MG | 2520 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameJW-7-25-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionJW-7-25-1 is a potent MELK inhibitor with biochemical IC50 of 5.0 nM.
-
DescriptionJW-7-25-1 is a potent MELK inhibitor with biochemical IC50 of 5.0 nM, also inhibits PIK3CA, mTOR, GSK3A and CDK7 with CI50 of 5-60 nM; exhibits a broad kinase selectivity profile with an S(35) score of 0.54 at 10 uM.
-
In Vitro——
-
In Vivo——
-
SynonymsJW-7-25-1 | JW 7-25-1 | JW7-25-1
-
PathwayPI3K/Akt/mTOR signaling
-
TargetMELK
-
RecptorMELK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1222998-57-3
-
Formula Weight516.524
-
Molecular FormulaC29H23F3N4O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C1N(C2=CC=C(N3CCNCC3)C(C(F)(F)F)=C2)C4=C(C=NC5=CC=C(C6=CC=C(O)C=C6)C=C54)C=C1
-
Chemical Name9-(4-hydroxyphenyl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693.
molnova catalog
related products
-
HTH-01-091
HTH-01-091 is a potent and selective, cell-permeable, ATP-competitive MELK inhibitor with biochemical IC50 of 10.5 nM.
-
MELK-T1
A novel, cell-permeable, potent and selective inhibitor of MELK kinase domain with IC50 of 37 nM.
-
OTS-167
OTS-167 (OTSSP-167)?is a highly potent and selective MELK inhibitor with IC50 of 0.41 nM.
