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ML197
CAS No. 1222891-88-4
ML197( NCGC00185963 | ML 197 )
Catalog No. M10847 CAS No. 1222891-88-4
ML197 is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameML197
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NoteResearch use only, not for human use.
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Brief DescriptionML197 is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively.
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DescriptionML197 is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively; inhibits CLK2, CLK3 and Dyrk1B with IC50 of 1327, 7448 and 1510 nM, extends intracellular NKX3.1 half-life in LNCaP prostate cancer cells.
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In Vitro——
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In Vivo——
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SynonymsNCGC00185963 | ML 197
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PathwayCell Cycle/DNA Damage
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TargetCLK
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RecptorCLK
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Research Area——
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Indication——
Chemical Information
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CAS Number1222891-88-4
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Formula Weight376.434
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Molecular FormulaC20H16N4O2S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylthiazol-4-yl)methyl)quinazolin-4-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rosenthal AS, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):3152-8.
2. Ewton DZ, et al. Mol Cancer Ther. 2011 Nov;10(11):2104-14.
3. Rosenthal AS, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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