CCR1 inhibitor 19e( —— )

Catalog No. M10832 CAS No. 1220026-26-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CCR1 inhibitor 19e
Note

Research use only, not for human use.
Brief Description

CCR1 inhibitor 19e is a novel potent, selective CCR1 antagonist with IC50 of 6.8 nM.
Description

CCR1 inhibitor 19e is a novel potent, selective CCR1 antagonist with IC50 of 6.8 nM, inhibits CCR1chemotaxis in THP-1 cells with IC50 of 28 nM.
In Vitro

CCR1 antagonist 9 (Compound 19e) blocks the CCR1 chemotaxis of THP-1 cells with an IC50 of 28 nM. CCR1 antagonist 9 also blocks hERG with an IC50 of 30 μM.
In Vivo

——
Synonyms

——
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

——
Indication

——

CAS Number

1220026-26-5
Formula Weight

425.438
Molecular Formula

C20H16FN5O3S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 83.33 mg/mL (195.87 mM)
SMILES

CS(=O)(=O)C1=NC=CC(=C1)CNC(=O)C2=CN=CC3=C2C=NN3C4=CC=C(C=C4)F
Chemical Name

1-(4-fluorophenyl)-N-((2-(methylsulfonyl)pyridin-4-yl)methyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxamide

1. Harcken C, et al. Bioorg Med Chem Lett. 2018 Dec 13. pii: S0960-894X(18)30958-2. doi: 10.1016/j.bmcl.2018.12.024.

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