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LGB-321
CAS No. 1210416-93-5
LGB-321( LGB 321 | LGB321 )
Catalog No. M10786 CAS No. 1210416-93-5
LGB-321 (LGB321) is a potent and specific pan-Pim inhibitor with Ki of 1/2.1/0.8 pM for Pim1/2/3, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1593 | Get Quote |
|
| 50MG | 3222 | Get Quote |
|
| 100MG | 4410 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameLGB-321
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NoteResearch use only, not for human use.
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Brief DescriptionLGB-321 (LGB321) is a potent and specific pan-Pim inhibitor with Ki of 1/2.1/0.8 pM for Pim1/2/3, respectively.
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DescriptionLGB-321 (LGB321) is a potent and specific pan-Pim inhibitor with Ki of 1/2.1/0.8 pM for Pim1/2/3, respectively; inhibits proliferation, mTOR-C1 signaling and phosphorylation of BAD in PIM2-dependent MM cell lines; shows activity in cell lines derived from diverse hematological lineages, including ALL, AML, NHL; shows activity in the KG-1 AML xenograft model, and synergizes with cytarabine.
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In Vitro——
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In Vivo——
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SynonymsLGB 321 | LGB321
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PathwayJAK/STAT Signaling
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TargetPim
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RecptorPim
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Research Area——
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Indication——
Chemical Information
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CAS Number1210416-93-5
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Formula Weight530.37
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Molecular FormulaC23H24Cl2F3N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1=C(N2C[C@@H](N)[C@H](O)[C@@H](C)C2)C=CN=C1)C3=NC(C4=C(F)C=CC=C4F)=C(F)C=C3.[H]Cl.[H]Cl
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Chemical NameN-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Garcia PD, et al. Clin Cancer Res. 2014 Apr 1;20(7):1834-45.
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