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Mirin
CAS No. 1198097-97-0
Mirin( Mirin )
Catalog No. M10709 CAS No. 1198097-97-0
A small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
|
| 5MG | 48 | In Stock |
|
| 10MG | 75 | In Stock |
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| 25MG | 136 | In Stock |
|
| 50MG | 221 | In Stock |
|
| 100MG | 407 | In Stock |
|
| 200MG | 531 | In Stock |
|
| 500MG | 853 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMirin
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity.
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DescriptionA small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity; prevents MRN-dependent activation of ATM (IC50=12 uM) without affecting ATM protein kinase activity; inhibits Mre11 nuclease activity at 100 uM, does not inhibit ExoIII nuclease activity; inhibits the G2 checkpoint, and blocks homology-directed repair (HDR) in mammalian cells.
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In Vitro——
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In Vivo——
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SynonymsMirin
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PathwayOthers
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TargetOther Targets
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RecptorMRN
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1198097-97-0
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Formula Weight220.2477
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Molecular FormulaC10H8N2O2S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 31 mg/mL
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SMILESO=C1NC(S/C1=C\C2=CC=C(O)C=C2)=N
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Chemical Name4(5H)-Thiazolone, 2-amino-5-[(4-hydroxyphenyl)methylene]-, (5Z)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dupré A, et al. Nat Chem Biol. 2008 Feb;4(2):119-25.
2. Lee JH, et al. J Biol Chem. 2013 May 3;288(18):12840-51.
3. Rozier L, et al. Mol Cell. 2013 Mar 28;49(6):1097-107.
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