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Home - Products - GPCR/G Protein - 5-HT Receptor - SB 206553

SB 206553

CAS No. 1197334-04-5

SB 206553( SB206553 )

Catalog No. M10703 CAS No. 1197334-04-5

SB 206553 is a potent and selective 5-HT2B/5-HT2C receptor antagonist with pA2 of 8.89 for rat 5-HT2B, pKi of 7.92 for human 5-HT2C, displays >80-fold selectivity over other 5-HT receptor subtypes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SB 206553
  • Note
    Research use only, not for human use.
  • Brief Description
    SB 206553 is a potent and selective 5-HT2B/5-HT2C receptor antagonist with pA2 of 8.89 for rat 5-HT2B, pKi of 7.92 for human 5-HT2C, displays >80-fold selectivity over other 5-HT receptor subtypes.
  • Description
    SB 206553 is a potent and selective 5-HT2B/5-HT2C receptor antagonist with pA2 of 8.89 for rat 5-HT2B, pKi of 7.92 for human 5-HT2C, displays >80-fold selectivity over other 5-HT receptor subtypes; exhibits anxiolytic-like properties both in vitro and in vivo.Anxiety Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SB206553
  • Pathway
    GPCR/G Protein
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    Neurological Disease
  • Indication
    Anxiety

Chemical Information

  • CAS Number
    1197334-04-5
  • Formula Weight
    328.8
  • Molecular Formula
    C17H16N4O.HCl
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(N1C(C(CC1)=C2)=CC3=C2N(C)C=C3)NC4=CC=CN=C4.[H]Cl
  • Chemical Name
    3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']dipyrrole-1(2H)-carboxamide hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Forbes IT, et al. J Med Chem. 1995 Jul 7;38(14):2524-30. 2. Upton N, et al. Eur J Pharmacol. 1998 Oct 16;359(1):33-40. 3. Kennett GA, et al. Br J Pharmacol. 1996 Feb;117(3):427-434. 4. Porras G, et al. Neuropsychopharmacology. 2002 Mar;26(3):311-24.
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