Cart
sales@molnova.com
TM2-115
CAS No. 1197196-47-6
TM2-115( TM2 115 )
Catalog No. M10699 CAS No. 1197196-47-6
A BIX-01294 derivative that inhibit malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 151 | In Stock |
|
| 5MG | 140 | In Stock |
|
| 10MG | 227 | In Stock |
|
| 25MG | 424 | In Stock |
|
| 50MG | 607 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTM2-115
-
NoteResearch use only, not for human use.
-
Brief DescriptionA BIX-01294 derivative that inhibit malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death.
-
DescriptionA BIX-01294 derivative that inhibit malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death; inhibits P. falciparum 3D7 parasites in culture with IC50 of 100 nM, >22-fold more potent than IC50 toward two human cell lines and one mouse cell line; significant reduces histone H3K4me3 levels in a concentration-dependent and exposure time-dependent manner in treatment of P. falciparum parasites.
-
In Vitro——
-
In Vivo——
-
SynonymsTM2 115
-
PathwayChromatin/Epigenetic
-
TargetHMTase
-
RecptorHMTase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1197196-47-6
-
Formula Weight489.664
-
Molecular FormulaC29H39N5O2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (203.82 mM)
-
SMILESCN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C)OC)OCC5=CC=CC=C5
-
Chemical Name7-(benzyloxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Malmquist NA, et al. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16708-13.
2. Malmquist NA, et al. Antimicrob Agents Chemother. 2015 Feb;59(2):950-9.
molnova catalog
related products
-
MI-2-2
MI-2-2 is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM).
-
GSK343
GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM, showing 60 fold selectivity against EZH1.
-
MS-049
A potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50 of 34±10 nM and 43±7 nM, respectively.
