TM2-115

CAS No. 1197196-47-6

TM2-115( TM2 115 )

Catalog No. M10699 CAS No. 1197196-47-6

A BIX-01294 derivative that inhibit malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 151 In Stock
5MG 140 In Stock
10MG 227 In Stock
25MG 424 In Stock
50MG 607 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    TM2-115
  • Note
    Research use only, not for human use.
  • Brief Description
    A BIX-01294 derivative that inhibit malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death.
  • Description
    A BIX-01294 derivative that inhibit malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death; inhibits P. falciparum 3D7 parasites in culture with IC50 of 100 nM, >22-fold more potent than IC50 toward two human cell lines and one mouse cell line; significant reduces histone H3K4me3 levels in a concentration-dependent and exposure time-dependent manner in treatment of P. falciparum parasites.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TM2 115
  • Pathway
    Chromatin/Epigenetic
  • Target
    HMTase
  • Recptor
    HMTase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1197196-47-6
  • Formula Weight
    489.664
  • Molecular Formula
    C29H39N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (203.82 mM)
  • SMILES
    CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C)OC)OCC5=CC=CC=C5
  • Chemical Name
    7-(benzyloxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Malmquist NA, et al. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16708-13. 2. Malmquist NA, et al. Antimicrob Agents Chemother. 2015 Feb;59(2):950-9.
molnova catalog
related products
  • MI-2-2

    MI-2-2 is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM).

  • GSK343

    GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM, showing 60 fold selectivity against EZH1.

  • MS-049

    A potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50 of 34±10 nM and 43±7 nM, respectively.