AZD 8683( AZD-8683 | AZD8683 )

Catalog No. M10685 CAS No. 1194737-07-9

COA

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HNMR

HPLC

MSDS

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Product Name

AZD 8683
Note

Research use only, not for human use.
Brief Description

A highly potent, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, inhibits M3 receptor in guinea pig trachea with pA2 of 9.4.
Description

A highly potent, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, inhibits M3 receptor in guinea pig trachea with pA2 of 9.4; reverse airflow obstruction by antagonizing para-sympathetic bronchoconstricting effects within the airways, shows potential for chronic obstructive pulmonary disease (COPD) management. COPD Phase 2 Discontinued.
In Vitro

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In Vivo

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Synonyms

AZD-8683 | AZD8683
Pathway

GPCR/G Protein
Target

mAChR
Recptor

mAChR
Research Area

Inflammation/Immunology
Indication

COPD

CAS Number

1194737-07-9
Formula Weight

542.518
Molecular Formula

C28H36BrN3O3
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

(R)-1-(2-oxo-2-(pyridin-2-ylamino)ethyl)-3-((1-phenylcycloheptane-1-carbonyl)oxy)quinuclidin-1-ium bromide

1. Mete A, et al. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6248-53. 2. Mastrodicasa MA, et al. Expert Opin Investig Drugs. 2017 Feb;26(2):161-174.

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