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AVN-322 free base
CAS No. 1194574-33-8
AVN-322 free base( AVN 323 free base )
Catalog No. M10683 CAS No. 1194574-33-8
A highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameAVN-322 free base
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NoteResearch use only, not for human use.
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Brief DescriptionA highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia.
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DescriptionA highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia; significantly restores both scopolamine- and MK-801-induced cognitive dysfunction and demonstrates antipsychotic potential.Alzheimer Disease Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsAVN 323 free base
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PathwayGPCR/G Protein
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number1194574-33-8
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Formula Weight357.432
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Molecular FormulaC17H19N5O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESCNC1=NN2C3=C(CN(CC3)C)C=NC2=C1S(=O)(=O)C4=CC=CC=C4
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Chemical NameN,7-dimethyl-3-(phenylsulfonyl)-6,7,8,9-tetrahydropyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-2-amine hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ivachtchenko AV, et al. Curr Alzheimer Res. 2017;14(3):268-294.
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