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TAK-259

CAS No. 1192348-73-4

TAK-259( TAK259 | TAK 259 )

Catalog No. M10667 CAS No. 1192348-73-4

A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TAK-259
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively.
  • Description
    A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively; shows antagonistic activity by a bladder strip test in rats with bladder outlet obstruction, ameliorates cystitis-induced urinary frequency in rats.Other Indication Phase 1 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TAK259 | TAK 259
  • Pathway
    GPCR/G Protein
  • Target
    Adrenergic Receptor
  • Recptor
    Adrenergic Receptor
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    1192348-73-4
  • Formula Weight
    374.236
  • Molecular Formula
    C14H13Cl2N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CS(=O)(=O)C1=C(C=C(C=C1)Cl)CN2C=C(C=C(C2=N)C(=O)N)Cl
  • Chemical Name
    5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sakauchi N, et al. J Med Chem. 2016 Apr 14;59(7):2989-3002.
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