DBPR108( DBPR-108 )

Catalog No. M10635 CAS No. 1186426-66-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

DBPR108
Note

Research use only, not for human use.
Brief Description

DBPR108 is a potent, selective, orally bioavailable and long-acting inhibitor of DPP4 with IC50 of 15 nM.
Description

DBPR108 is a potent, selective, orally bioavailable and long-acting inhibitor of DPP4 with IC50 of 15 nM, >3,000-fold selectivity over DPP8, DPP9, FAP and DPP-II; exhibits excellent human plasma DPP-IV inhibition with IC50 of 5 nM, suppresses blood glucose elevation in vivo, demonstrates potential treatment of type 2 diabetes mellitus.Diabetes Phase 1 Clinical.
In Vitro

——
In Vivo

——
Synonyms

DBPR-108
Pathway

Metabolic Enzyme/Protease
Target

DPP
Recptor

DPP
Research Area

Metabolic Disease
Indication

Diabetes

CAS Number

1186426-66-3
Formula Weight

324.3937
Molecular Formula

C16H25FN4O2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

N#C[C@H]1N(C(CNC(C)(C)CC(N2CCCC2)=O)=O)C[C@@H](F)C1
Chemical Name

2-Pyrrolidinecarbonitrile, 1-[2-[[1,1-dimethyl-3-oxo-3-(1-pyrrolidinyl)propyl]amino]acetyl]-4-fluoro-, (2S,4S)-

1. Yeh TK, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3596-600.

Calculator

molnova catalog