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XX-650-23
CAS No. 117739-40-9
XX-650-23( XX 650 23 )
Catalog No. M10601 CAS No. 117739-40-9
XX-650-23 is a small molecule inhibitor of CREB, blocks CREB/CBP interaction (IC50=3.2 uM) and disrupts CREB-driven gene expression.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 5MG | 88 | In Stock |
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| 10MG | 141 | In Stock |
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| 25MG | 282 | In Stock |
|
| 50MG | 462 | In Stock |
|
| 100MG | 644 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1349 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameXX-650-23
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NoteResearch use only, not for human use.
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Brief DescriptionXX-650-23 is a small molecule inhibitor of CREB, blocks CREB/CBP interaction (IC50=3.2 uM) and disrupts CREB-driven gene expression.
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DescriptionXX-650-23 is a small molecule inhibitor of CREB, blocks CREB/CBP interaction (IC50=3.2 uM) and disrupts CREB-driven gene expression; suppresses AML cell lines growth with IC50 of 0.87-2.3 uM, specifically disrupts CREB-driven transcription, induces apoptosis and cell-cycle arrest; significantly increases survival of cell line- and patient-derived xenograft mice with no toxicity to normal hematopoietic cells or animals.
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In Vitro——
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In Vivo——
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SynonymsXX 650 23
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PathwayNuclear Receptor/Transcription Factor
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TargetCREB/CBP
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RecptorCREB/CBP
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Research Area——
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Indication——
Chemical Information
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CAS Number117739-40-9
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Formula Weight288.306
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Molecular FormulaC18H12N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (346.86 mM)
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SMILESO=C(NC1=CC=C(C#N)C=C1)C2=C(O)C=C3C=CC=CC3=C2
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Chemical NameN-(4-cyanophenyl)-3-hydroxy-2-naphthamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mitton B, et al. Leukemia. 2016 Dec;30(12):2302-2311.
2. Fran?ois S, et al. J Virol. 2016 Sep 12;90(19):8686-97.
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