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Lanperisone
CAS No. 116287-14-0
Lanperisone( NK 433 )
Catalog No. M10560 CAS No. 116287-14-0
Lanperisone (NK 433) is a centrally acting muscle relaxant that selectively kills of K-ras mutant cancer cells in a cell cycle-independent fashion.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameLanperisone
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NoteResearch use only, not for human use.
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Brief DescriptionLanperisone (NK 433) is a centrally acting muscle relaxant that selectively kills of K-ras mutant cancer cells in a cell cycle-independent fashion.
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DescriptionLanperisone (NK 433) is a centrally acting muscle relaxant that selectively kills of K-ras mutant cancer cells in a cell cycle-independent fashion; shows potent and selective activity against K-rasG12D MEFs with IC50 of 4 uM in the CTG viability assay; causes a large population of cells with sub-2N DNA content, induces oxidative stress, but not in wild-type MEFs; suppresses the growth of K-ras-driven tumors without overt toxicity in mice; orally bioactive.
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In Vitro——
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In Vivo——
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SynonymsNK 433
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PathwayMAPK/ERK Signaling
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TargetRas
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RecptorRas
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Research Area——
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Indication——
Chemical Information
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CAS Number116287-14-0
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Formula Weight285.305
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Molecular FormulaC15H18F3NO
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=CC=C(C(F)(F)F)C=C1)[C@H](C)CN2CCCC2
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Chemical Name(2R)-2-methyl-3-pyrrolidin-1-yl-1-[4-(trifluoromethyl)phenyl]propan-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shaw AT, et al. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8773-8.
2. Sakitama K, et al. Eur J Pharmacol. 1997 Oct 22;337(2-3):175-87.
3. Glasauer A, et al. Biochem Pharmacol. 2014 Nov 1;92(1):90-101.
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