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WYE-125132
CAS No. 1144068-46-1
WYE-125132( WYE-132 | WYE125132 )
Catalog No. M10513 CAS No. 1144068-46-1
A potent, specific, ATP-competitive and orally active mTOR inhibitor with IC50 of 0.19 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 84 | In Stock |
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| 5MG | 73 | In Stock |
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| 10MG | 112 | In Stock |
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| 25MG | 188 | In Stock |
|
| 50MG | 272 | In Stock |
|
| 100MG | 403 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameWYE-125132
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific, ATP-competitive and orally active mTOR inhibitor with IC50 of 0.19 nM.
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DescriptionA potent, specific, ATP-competitive and orally active mTOR inhibitor with IC50 of 0.19 nM; dispalys high selectivity (>5,000-fold) over PI3Ks, the PI3K-related kinases hSMG1 and ATR, and a panel of 230 protein kinases; inhibits mTORC1-dependent phosphorylation of S6K(T389) and mTORC2-dependent phosphorylation of AKT(S473), inhibits cancer cell proliferation, cell cycle progression, and induces apoptosis; shows potent single-agent antitumor activity against multiple cancer models.
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In Vitro——
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In Vivo——
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SynonymsWYE-132 | WYE125132
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PathwayPI3K/Akt/mTOR signaling
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TargetmTOR
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RecptormTOR
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1144068-46-1
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Formula Weight519.5954
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Molecular FormulaC27H33N7O4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 62 mg/mL
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SMILESO=C(NC)NC1=CC=C(C2=NC(N3CC(O4)CCC4C3)=C5C(N(C(CC6)CCC76OCCO7)N=C5)=N2)C=C1
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Chemical NameUrea, N-[4-[1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yu K, et al. Cancer Res. 2010 Jan 15;70(2):621-31.
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