WYE-125132( WYE-132 | WYE125132 )

Catalog No. M10513 CAS No. 1144068-46-1

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Product Name

WYE-125132
Note

Research use only, not for human use.
Brief Description

A potent, specific, ATP-competitive and orally active mTOR inhibitor with IC50 of 0.19 nM.
Description

A potent, specific, ATP-competitive and orally active mTOR inhibitor with IC50 of 0.19 nM; dispalys high selectivity (>5,000-fold) over PI3Ks, the PI3K-related kinases hSMG1 and ATR, and a panel of 230 protein kinases; inhibits mTORC1-dependent phosphorylation of S6K(T389) and mTORC2-dependent phosphorylation of AKT(S473), inhibits cancer cell proliferation, cell cycle progression, and induces apoptosis; shows potent single-agent antitumor activity against multiple cancer models.
In Vitro

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In Vivo

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Synonyms

WYE-132 | WYE125132
Pathway

PI3K/Akt/mTOR signaling
Target

mTOR
Recptor

mTOR
Research Area

Cancer
Indication

——

CAS Number

1144068-46-1
Formula Weight

519.5954
Molecular Formula

C27H33N7O4
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 62 mg/mL
SMILES

O=C(NC)NC1=CC=C(C2=NC(N3CC(O4)CCC4C3)=C5C(N(C(CC6)CCC76OCCO7)N=C5)=N2)C=C1
Chemical Name

Urea, N-[4-[1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methyl-

1. Yu K, et al. Cancer Res. 2010 Jan 15;70(2):621-31.

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