Cart
sales@molnova.com
CI-976
CAS No. 114289-47-3
CI-976( PD 128042 )
Catalog No. M10507 CAS No. 114289-47-3
CI-976 (PD 128042) is a potent, selective, orally bioavailable inhibitor of ACAT-1 (Acetyl-CoA acetyltransferase 1) with IC50 of 73 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 88 | In Stock |
|
| 5MG | 56 | In Stock |
|
| 10MG | 105 | In Stock |
|
| 25MG | 231 | In Stock |
|
| 50MG | 379 | In Stock |
|
| 100MG | 630 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCI-976
-
NoteResearch use only, not for human use.
-
Brief DescriptionCI-976 (PD 128042) is a potent, selective, orally bioavailable inhibitor of ACAT-1 (Acetyl-CoA acetyltransferase 1) with IC50 of 73 nM.
-
DescriptionCI-976 (PD 128042) is a potent, selective, orally bioavailable inhibitor of ACAT-1 (Acetyl-CoA acetyltransferase 1) with IC50 of 73 nM; decreases plasma total cholesterol, very low density lipoprotein (VLDL) cholesterol, LDL cholesterol, apolipoprotein B, liver cholesteryl esters, and VLDL and LDL cholesteryl ester content in rabbits.Atherosclerosis Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsPD 128042
-
PathwayOthers
-
TargetOther Targets
-
RecptorOther Targets
-
Research AreaCardiovascular Disease
-
IndicationAtherosclerosis
Chemical Information
-
CAS Number114289-47-3
-
Formula Weight393.568
-
Molecular FormulaC23H39NO4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (254.09 mM)
-
SMILESCCCCCCCCCCC(C)(C)C(=O)NC1=C(C=C(C=C1OC)OC)OC
-
Chemical Name2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-dodecanamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Field FJ, et al. Lipids. 1991 Jan;26(1):1-8.
2. O'Brien PM, et al. J Med Chem. 1994 Jun 10;37(12):1810-22.
3. Krause BR, et al. J Lipid Res. 1993 Feb;34(2):279-94.
4. Baba T, et al. Mol Cell Biochem. 2013 Apr;376(1-2):151-61.
molnova catalog
related products
-
Dihydroguaiaretic ac...
Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress.
-
Amlodipine aspartic ...
Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine aspartic acid impurity is the impurity of Amlodipine aspartic acid.
-
CAY10781
CAY10781 is an inhibitor of the protein-protein interaction between neuropilin-1 (NRP-1) and VEGF-A.1It inhibits the interaction by 43% when used at a concentration of 12.5 μM. CAY10781 also inhibits VEGF-A-induced phosphorylation of VEGFR2 in catecholamine A-differentiated (CAD) cells when used at the same concentration.
