Digitonin( Digitin | NSC 23471 | NSC 237417 )

Catalog No. M10393 CAS No. 11024-24-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Digitonin
Note

Research use only, not for human use.
Brief Description

Digitonin is a steroidal saponin (saraponin) obtained from the foxglove plant Digitalis purpurea.
Description

Digitonin is a steroidal saponin (saraponin) obtained from the foxglove plant Digitalis purpurea. It's aglycone is digitogenin, a spirostan steroid. It has been investigated as a detergent, as it effectively water-solubilizes lipids.
In Vitro

Digitonin, a detergent that increases cell permeability by binding to cholesterol molecules in the cell membrane, can increase cisplatin accumulation and reduce tumour growth in vitro.
In Vivo

In the liver parenchyma the concentrations are of the same magnitude. Measured with the 133Xe-clearance technique, Digitonin does not alter the tumor blood flow. Digitonin enhances the tumor-growth retarding effect of CBDCA given intra-aterially at 5 mg/kg but not at 25 mg/kg.
Synonyms

Digitin | NSC 23471 | NSC 237417
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Other Indications
Indication

——

CAS Number

11024-24-1
Formula Weight

1229.34
Molecular Formula

C56H92O29
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

C[C@@H]1CC[C@]2(O[C@H]3[C@H]([C@H]4[C@@H]5CC[C@H]6C[C@H]([C@@H](C[C@@]6([C@H]5CC[C@@]4([C@H]3[C@@H]2C)C)C)O)O[C@@H]7O[C@@H]([C@@H]([C@@H]([C@H]7O)O)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O[C@@H]9O[C@@H]([C@@H]([C@@H]([C@H]9O)O[C@@H]%10O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)CO)O)CO)O[C@@H]%11OC[C@H]([C@@H]([C@H]%11O)O)O)O)CO)CO)O)OC1
Chemical Name

beta-D-Galactopyranoside, (2alpha,3beta,5alpha,15beta,25R)-2,15-dihydroxyspirostan-3-yl O-beta-D-glucopyranosyl-(1-3)-O-beta-D-galactopyranosyl-(1-2)-O-(beta-D-xylopyranosyl-(1-3))-O-beta-D-glucopyranosyl-(1-4)-

1. Frenkel N, et al. J Phys Chem B. 2014 Dec 18;118(50):14632-9.

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