Cart
sales@molnova.com
Tepotinib
CAS No. 1100598-32-0
Tepotinib( EMD-1214063 | EMD 1214063 | EMD1214063 )
Catalog No. M10385 CAS No. 1100598-32-0
Tepotinib (EMD-1214063) is a potent and highly selective c-Met inhibitor with IC50 of 3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 54 | In Stock |
|
| 5MG | 102 | In Stock |
|
| 10MG | 185 | In Stock |
|
| 25MG | 398 | In Stock |
|
| 50MG | 518 | In Stock |
|
| 100MG | 615 | In Stock |
|
| 500MG | 1305 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTepotinib
-
NoteResearch use only, not for human use.
-
Brief DescriptionTepotinib (EMD-1214063) is a potent and highly selective c-Met inhibitor with IC50 of 3 nM.
-
DescriptionTepotinib (EMD-1214063) is a potent and highly selective c-Met inhibitor with IC50 of 3 nM; shows selectivity versus a panel of 242 human kinases; inhibits c-Met phosphorylation and downstream signaling in a dose-dependent fashion; induces regression of human tumors in murine xenograft models.Liver Cancer Phase 2 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsEMD-1214063 | EMD 1214063 | EMD1214063
-
PathwayAngiogenesis
-
Targetc-Met/HGFR
-
RecptorAXL|c-Met|TrkA
-
Research AreaCancer
-
IndicationLiver Cancer
Chemical Information
-
CAS Number1100598-32-0
-
Formula Weight492.5716
-
Molecular FormulaC29H28N6O2
-
Purity>98% (HPLC)
-
SolubilityDMSO: 27 mg/mL
-
SMILESN#CC1=CC=CC(C(C=C2)=NN(CC3=CC=CC(C4=NC=C(OCC5CCN(C)CC5)C=N4)=C3)C2=O)=C1
-
Chemical NameBenzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Bladt F, et al. Clin Cancer Res. 2013 Jun 1;19(11):2941-51.
2. Mikami K, et al. Mol Cancer Res. 2015 Dec;13(12):1544-53.
molnova catalog
related products
-
TAE226
NVP-TAE226 is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2(IC50=3.5 nM); 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.
-
SRI 31215
SRI 31215 a small molecule that acts as a triplex inhibitor of matriptase hepsin and HGFA and mimics the activity of HAI-1/2 endogenous inhibitors of HGF activation with IC50s of 0.69 μM 0.65 μM 0.3 μM.
-
AMG-458
AMG-458 (AMG458) is a potent, selective, orally bioavailable c-Met inhibitor with Ki of 1.2 nM.
