PF-04531083( PF-4531083 )

Catalog No. M10319 CAS No. 1079400-07-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PF-04531083
Note

Research use only, not for human use.
Brief Description

PF-04531083 (PF 4531083) is a potent and selective, orally available sodium channel Nav1.8 blocker for treatment of pain.
Description

PF-04531083 (PF 4531083) is a potent and selective, orally available sodium channel Nav1.8 blocker for treatment of pain. Pain Phase 2 Discontinued.
In Vitro

——
In Vivo

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Synonyms

PF-4531083
Pathway

Membrane Transporter/Ion Channel
Target

Sodium Channel
Recptor

Sodium Channel
Research Area

Neurological Disease
Indication

Pain

CAS Number

1079400-07-9
Formula Weight

357.798
Molecular Formula

C17H16ClN5O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (279.49 mM)
SMILES

CN1C(=CC=N1)C(=O)NC2=NC(=C(C=C2)C3=C(C=CC(=C3)OC)Cl)N
Chemical Name

N-[6-amino-5-(2-chloro-5-methoxyphenyl)pyridin-2-yl]-2-methylpyrazole-3-carboxamide

1. Bagal SK, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3690-9.

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