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LDN193189 hydrochloride
CAS No. 1062368-62-0
LDN193189 hydrochloride( LDN 193189 hydrochloride | LDN-193189 hydrochloride )
Catalog No. M10278 CAS No. 1062368-62-0
LDN193189 is a potent, selective BMP type I receptor that inhibits BMP4-induced phosphorylation of SMAD1/5/8 with IC50 of 5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 80 | In Stock |
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| 25MG | 146 | In Stock |
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| 50MG | 254 | In Stock |
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| 100MG | 381 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLDN193189 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionLDN193189 is a potent, selective BMP type I receptor that inhibits BMP4-induced phosphorylation of SMAD1/5/8 with IC50 of 5 nM.
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DescriptionLDN193189 is a potent, selective BMP type I receptor that inhibits BMP4-induced phosphorylation of SMAD1/5/8 with IC50 of 5 nM, displays >200-fold selectivity for BMP signaling over TGF-β signaling (IC50>1,000 nM); efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 (IC50=5 nM and 30 nM, respectively), with weaker effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7; also blocks the transcriptional activity induced by either constitutively active ALK2 R206H or ALK2 Q207D mutant proteins, affects BMP-induced osteoblast differentiation, attenuates ectopic ossification in vivo.
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In Vitro——
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In Vivo——
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SynonymsLDN 193189 hydrochloride | LDN-193189 hydrochloride
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PathwayAngiogenesis
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TargetALK
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RecptorALK2|ALK3
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1062368-62-0
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Formula Weight552.3261
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Molecular FormulaC25H26Cl4N6
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Purity>98% (HPLC)
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SolubilityH2O: 20 mg/mL
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SMILES[H]Cl.C1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=CC=NC6=CC=CC=C16
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Chemical NameQuinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yu PB, et al. Nat Med. 2008 Dec;14(12):1363-9.
2. Cuny GD, et al. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4388-92.
3. Cannon JE, et al. Br J Pharmacol. 2010 Sep;161(1):140-9.
4. Steinbicker AU, et al. Blood. 2011 May 5;117(18):4915-23.
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