Cart
sales@molnova.com
ABD328
CAS No. 1055896-19-9
ABD328( ABD-328 | ABD 328 )
Catalog No. M10254 CAS No. 1055896-19-9
ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameABD328
-
NoteResearch use only, not for human use.
-
Brief DescriptionABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo.
-
DescriptionABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo; inhibits TNF-induced activation of the NF-κB pathway, ERK, JNK and MAPKs in osteoclasts and macrophages, suppresses inflammatory arthritis, inhibits joint destruction and prevented systemic bone loss in mice model of rheumatoid arthritis.
-
In Vitro——
-
In Vivo——
-
SynonymsABD-328 | ABD 328
-
PathwayApoptosis
-
TargetNF-κB
-
RecptorNF-κB
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1055896-19-9
-
Formula Weight337.24
-
Molecular FormulaC18H18Cl2O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC1=CC(=CC=C1C2=C(C=C(C=C2)Cl)Cl)C(=O)CCCCCO
-
Chemical Name1-(2',4'-dichloro-[1,1'-biphenyl]-4-yl)-6-hydroxyhexan-1-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Coste E, et al. Ann Rheum Dis. 2015 Jan;74(1):220-6.
2. Idris AI, et al. Calcif Tissue Int. 2010 Dec;87(6):525-32.
molnova catalog
related products
-
SP-100030
SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both.
-
Anti-inflammatory ag...
Anti-inflammatory agent 51 is an amide/sulfonamide derivative with anti-inflammatory and potentially anti-tumor activity and inhibition of NF-κB activation, which can be used to study acute lung injury and ulcerative colitis.
-
Hesperidin methylcha...
Hesperidin methylchalcone is the Citrus original products with powerful antioxidant activity. It can suppresse experimental gout arthritis in mice by inhibiting NF-κB activation.
