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AZD 9164

CAS No. 1034978-04-5

AZD 9164( AZD9164 | AZD-9164 )

Catalog No. M10172 CAS No. 1034978-04-5

A novel highly potent, selective, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, 10-fold selectivity over M2 (pIC50=9.0).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    AZD 9164
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel highly potent, selective, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, 10-fold selectivity over M2 (pIC50=9.0).
  • Description
    A novel highly potent, selective, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, 10-fold selectivity over M2 (pIC50=9.0); demonstrates potential as a treatment for COPD.COPD Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AZD9164 | AZD-9164
  • Pathway
    GPCR/G Protein
  • Target
    mAChR
  • Recptor
    mAChR
  • Research Area
    Inflammation/Immunology
  • Indication
    COPD

Chemical Information

  • CAS Number
    1034978-04-5
  • Formula Weight
    465.633
  • Molecular Formula
    C29H38FN2O2+
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C1=CC=CC=C1)(C(=O)OC2C[N+]3(CCC2CC3)CCC4=CC=C(C=C4)F)N5CCCCC5
  • Chemical Name
    (R)-1-(4-fluorophenethyl)-3-(((S)-2-phenyl-2-(piperidin-1-yl)propanoyl)oxy)quinuclidin-1-ium

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mete A, et al. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6248-53. 2. Bjermer L, et al. Respir Med. 2013 Jan;107(1):84-90. 3. Mastrodicasa MA, et al. Expert Opin Investig Drugs. 2017 Feb;26(2):161-174.
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