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Suvorexant
CAS No. 1030377-33-3
Suvorexant( MK-4305 )
Catalog No. M10147 CAS No. 1030377-33-3
A potent, CNS penetrant, orally available, dual orexin receptor antagonist with Ki of 0.55 and 0.35 nM for OX1R and OX2R, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameSuvorexant
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, CNS penetrant, orally available, dual orexin receptor antagonist with Ki of 0.55 and 0.35 nM for OX1R and OX2R, respectively.
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DescriptionA potent, CNS penetrant, orally available, dual orexin receptor antagonist with Ki of 0.55 and 0.35 nM for OX1R and OX2R, respectively; significantly and dose-dependently reduces locomotor activity and promotes sleep in rats.Sleep Disorder Launched.
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In Vitro——
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In Vivo——
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SynonymsMK-4305
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PathwayGPCR/G Protein
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TargetOrexin Receptor
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RecptorOrexin Receptor
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Research AreaNeurological Disease
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IndicationSleep Disorder
Chemical Information
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CAS Number1030377-33-3
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Formula Weight450.92
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Molecular FormulaC23H23ClN6O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(N1CCN(C2=NC3=CC(Cl)=CC=C3O2)CC[C@H]1C)C4=CC(C)=CC=C4N5N=CC=N5
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Chemical Name(R)-(4-(5-chlorobenzo[d]oxazol-2-yl)-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cox CD, et al. J Med Chem. 2010 Jul 22;53(14):5320-32.
2. Winrow CJ, et al. J Neurogenet. 2011 Mar;25(1-2):52-61.
3. Sun H, et al. Sleep. 2013 Feb 1;36(2):259-67.
4. Hopkins CR. ACS Chem Neurosci. 2012 Sep 19;3(9):647-8.
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