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VX-222
CAS No. 1026785-59-0
VX-222( VCH-222 | Lomibuvir )
Catalog No. M10130 CAS No. 1026785-59-0
A potent and selective, nonnucleoside inhibitor of HCV NS5B polymerase inhibitor with Kd of 17 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 68 | In Stock |
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| 5MG | 123 | In Stock |
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| 10MG | 206 | In Stock |
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| 25MG | 426 | In Stock |
|
| 50MG | 617 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVX-222
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective, nonnucleoside inhibitor of HCV NS5B polymerase inhibitor with Kd of 17 nM.
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DescriptionA potent and selective, nonnucleoside inhibitor of HCV NS5B polymerase inhibitor with Kd of 17 nM; inhibits the 1b/Con1 HCV subgenomic replicon with EC50 of 17 nM, the M423I and A486S variants remaine susceptible to VX-222; exhibits non-competitive and selective inhibition in HCV NS5B of genotype 1a and 1b, with IC50 of 0.94 and 1.2 uM, respectively; displays fine pharmacokinetic pro le in rats and dogs.HCV Infection Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsVCH-222 | Lomibuvir
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PathwayMicrobiology/Virology
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TargetHCV
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RecptorHCVNS5B1a|HCVNS5B1b
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Research AreaInfection
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IndicationHCV Infection
Chemical Information
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CAS Number1026785-59-0
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Formula Weight445.6147
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Molecular FormulaC25H35NO4S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 32 mg/mL
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SMILESCC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O
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Chemical Name2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yi G, et al. Antimicrob Agents Chemother. 2012 Feb;56(2):830-7.
2. Jiang M, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5456-65.
3. Di Bisceglie AM, et al. Eur J Gastroenterol Hepatol. 2014 Jul;26(7):761-73.
molnova catalog
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