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MK-3577
CAS No. 1019112-29-8
MK-3577( MK 3577 | MK3577 )
Catalog No. M10091 CAS No. 1019112-29-8
A potent, oral active glucagon receptor antagonist blocking the glucagon effect for the treatment of T2DM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1143 | Get Quote |
|
| 50MG | 2322 | Get Quote |
|
| 100MG | 3060 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMK-3577
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, oral active glucagon receptor antagonist blocking the glucagon effect for the treatment of T2DM.
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DescriptionA potent, oral active glucagon receptor antagonist blocking the glucagon effect for the treatment of T2DM; inhibits glucagon-mediated cAMP increases in CHO cells expressing the human glucagon receptor with IC50 of 8.3 nM.Diabetes Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsMK 3577 | MK3577
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PathwayGPCR/G Protein
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TargetGlucagon Receptor
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RecptorGlucagon Receptor
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Research AreaMetabolic Disease
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IndicationDiabetes
Chemical Information
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CAS Number1019112-29-8
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Formula Weight521.03
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Molecular FormulaC30H30ClFN2O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCC(C1=CC=C(C=C1)C(=O)NCCC(=O)O)C(C2=CC=C(C=C2)Cl)C3=CNC4=C3C=C(C=C4F)C
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Chemical Name3-(4-((1R,2S)-1-(4-chlorophenyl)-1-(7-fluoro-5-methyl-1H-indol-3-yl)pentan-2-yl)benzamido)propanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Peng JZ, et al. AAPS J. 2014 Nov;16(6):1259-70.
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