CCX-354( GSK-2941266 | CCX354 | CCX354-C )

Catalog No. M10066 CAS No. 1010073-75-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CCX-354
Note

Research use only, not for human use.
Brief Description

CCX-354 (GSK-2941266, CCX354-C, CCX354) is a potent, selective, orally-available CCR1 antagonist for the treatment of inflammatory diseases.
Description

CCX-354 (GSK-2941266, CCX354-C, CCX354) is a potent, selective, orally-available CCR1 antagonist for the treatment of inflammatory diseases such as rheumatoid arthritis (RA).Rheumatoid Arthritis Phase 2 Clinical.
In Vitro

CCX354 shows potent activities in the chemotaxis assay, with IC50 < 100 nM.
In Vivo

In vivo, CCX354 has in vivo anti-inflammatory activity and has superior pharmacokinetic properties.
Synonyms

GSK-2941266 | CCX354 | CCX354-C
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

Inflammation/Immunology
Indication

Rheumatoid Arthritis

CAS Number

1010073-75-2
Formula Weight

451.915
Molecular Formula

C22H22ClN7O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (221.28 mM)
SMILES

COC1=C(C=CC(=C1)N2CCN(CC2)C(=O)CN3C4=C(C=CC=N4)C(=N3)C5=NC=CN5)Cl
Chemical Name

2-(3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(4-(4-chloro-3-methoxyphenyl)piperazin-1-yl)ethan-1-one

1. Tak PP, et al. Ann Rheum Dis. 2013 Mar;72(3):337-44. 2. Harcken C, et al. Bioorg Med Chem Lett. 2018 Nov 9. pii: S0960-894X(18)30880-1.

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