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PDK1 inhibitor 7
CAS No. 1001409-50-2
PDK1 inhibitor 7( PDK1 inhibitor MP7 )
Catalog No. M10016 CAS No. 1001409-50-2
A potent, selective PDK1 inhibitor with IC50 of 1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 237 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePDK1 inhibitor 7
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective PDK1 inhibitor with IC50 of 1 nM.
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DescriptionA potent, selective PDK1 inhibitor with IC50 of 1 nM, displays >3,000-fold selectivity against a panel of 256 kinases; specifically inhibits cellular PDK1 T-loop phosphorylation (Ser-241), inhibits p-RSK S221 in PC-3 cells with EC50 of 300 nM, inhibits colony formation in a subset of cancer cell lines (4 of 10) and primary xenograft tumor lines (9 of 57).
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In Vitro——
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In Vivo——
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SynonymsPDK1 inhibitor MP7
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PathwayPI3K/Akt/mTOR signaling
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TargetPDK
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RecptorPDK
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1001409-50-2
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Formula Weight516.505
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Molecular FormulaC28H22F2N4O4
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL 193.61 mM;H2O : < 0.1 mg/mL
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SMILESC1=CC=C(C=C1)C(COC2=CC3=C(C=C2)NC(=O)N3)NC(=O)C4=CC=CN(C4=O)CC5=CC(=C(C=C5)F)F
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Chemical Name(R)-1-(3,4-difluorobenzyl)-2-oxo-N-(2-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)oxy)-1-phenylethyl)-1,2-dihydropyridine-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nagashima K, et al. J Biol Chem. 2011 Feb 25;286(8):6433-48.
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