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M-31850

CAS No. 281224-40-6

M-31850 ( 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-(iminodi-2,1-ethanediyl)bis- )

Catalog No. M24195 CAS No. 281224-40-6

M-31850 is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor(human HexA and human HexB with IC50s of 6.0 μM and 3.1 μM, respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    M-31850
  • Note
    Research use only, not for human use.
  • Brief Description
    M-31850 is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor(human HexA and human HexB with IC50s of 6.0 μM and 3.1 μM, respectively).
  • Description
    M-31850 is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor(human HexA and human HexB with IC50s of 6.0 μM and 3.1 μM, respectively). IT also competitively inhibits β-N-acetyl-D-hexosaminidase OfHex2 with a Ki of 2.5 μM.
  • Synonyms
    1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-(iminodi-2,1-ethanediyl)bis-
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    β-hexosaminidase (Hex)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    281224-40-6
  • Formula Weight
    463.5
  • Molecular Formula
    C28H21N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:5 mg/mL?(10.79 mM;?ultrasonic and adjust pH to 6 with HCl)
  • SMILES
    C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCNCCN4C(=O)C5=CC=CC6=C5C(=CC=C6)C4=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Michael B Tropak, et al. High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones. Chem Biol. 2007 Feb;14(2):153-64.
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