M-110

CAS No. 1395048-49-3

M-110( M110 )

Catalog No. M11650 CAS No. 1395048-49-3

M-110 is a potent, selective inhibitor of PIM kinase family with preference for PIM-3 with IC50 of 0.047, 2.5 and 2.5 uM for PIM3, PIM1 and PIM2, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 87 Get Quote
10MG 140 Get Quote
25MG 267 Get Quote
50MG 493 Get Quote
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Biological Information

  • Product Name
    M-110
  • Note
    Research use only, not for human use.
  • Brief Description
    M-110 is a potent, selective inhibitor of PIM kinase family with preference for PIM-3 with IC50 of 0.047, 2.5 and 2.5 uM for PIM3, PIM1 and PIM2, respectively.
  • Description
    M-110 is a potent, selective inhibitor of PIM kinase family with preference for PIM-3 with IC50 of 0.047, 2.5 and 2.5 uM for PIM3, PIM1 and PIM2, respectively; dispplays excellent selectivity in a panel of 261 kinases; inhibits the growth of DU-145 cells with IC50 of 0.9 uM, significantly reduces pSTAT3(Tyr705) expression without affecting the expression of STAT3, also attenuates the IL-6-induced increase in pSTAT3(Tyr705), shows no effect on phosphorylation of STAT5 on Tyr694 in 22Rv1 cells.
  • In Vitro
    M-110 (0.01-10 μM; 72 hours) inhibiting the growth of DU-145 cells with an IC50?value of 0.9 μM. M-110 has no activity on normal human peripheral blood mononuclear cells up to 40 μM.M-110 (10 μM; 18 hours) inhibits STAT3 Tyr705?phosphorylation.M-110 inhibits the expression of active STAT3 through inhibition of PIM-3. M-110 also inhibits the proliferation of 22Rv1, PC3, and SW480 cells, with IC50?values of 0.6 to 0.8 μM.Cell Viability Assay Cell Line:DU-145 cells Concentration:0.01, 0.1, 1, 10 μM Incubation Time:72 hours Result:Inhibiting the growth of DU-145 cells with an IC50?value of 0.9 μM.Western Blot Analysis Cell Line:DU-145 cells Concentration:10 μM Incubation Time:18 hours Result:Reduced the expression of p-STAT3 Tyr705?to 23.5%, compared with untreated cells without affecting the expression of STAT3.?
  • In Vivo
    ——
  • Synonyms
    M110
  • Pathway
    JAK/STAT Signaling
  • Target
    Pim
  • Recptor
    Pim
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1395048-49-3
  • Formula Weight
    445.9424
  • Molecular Formula
    C22H28ClN5O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(N/N=C(C1=CC=C(Cl)C=C1O)\CC)C2=CC=NC(NCCCN3CCOCC3)=C2
  • Chemical Name
    4-Pyridinecarboxylic acid, 2-[[3-(4-morpholinyl)propyl]amino]-, 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chang M, et al. Mol Cancer Ther. 2010 Sep;9(9):2478-87. 2. Siu A, et al. Oncotarget. 2011 Dec;2(12):1134-44.
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