
M-110
CAS No. 1395048-49-3
M-110( M110 )
Catalog No. M11650 CAS No. 1395048-49-3
M-110 is a potent, selective inhibitor of PIM kinase family with preference for PIM-3 with IC50 of 0.047, 2.5 and 2.5 uM for PIM3, PIM1 and PIM2, respectively.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 87 | Get Quote |
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10MG | 140 | Get Quote |
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25MG | 267 | Get Quote |
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50MG | 493 | Get Quote |
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100MG | Get Quote | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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Biological Information
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Product NameM-110
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NoteResearch use only, not for human use.
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Brief DescriptionM-110 is a potent, selective inhibitor of PIM kinase family with preference for PIM-3 with IC50 of 0.047, 2.5 and 2.5 uM for PIM3, PIM1 and PIM2, respectively.
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DescriptionM-110 is a potent, selective inhibitor of PIM kinase family with preference for PIM-3 with IC50 of 0.047, 2.5 and 2.5 uM for PIM3, PIM1 and PIM2, respectively; dispplays excellent selectivity in a panel of 261 kinases; inhibits the growth of DU-145 cells with IC50 of 0.9 uM, significantly reduces pSTAT3(Tyr705) expression without affecting the expression of STAT3, also attenuates the IL-6-induced increase in pSTAT3(Tyr705), shows no effect on phosphorylation of STAT5 on Tyr694 in 22Rv1 cells.
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In VitroM-110 (0.01-10 μM; 72 hours) inhibiting the growth of DU-145 cells with an IC50?value of 0.9 μM. M-110 has no activity on normal human peripheral blood mononuclear cells up to 40 μM.M-110 (10 μM; 18 hours) inhibits STAT3 Tyr705?phosphorylation.M-110 inhibits the expression of active STAT3 through inhibition of PIM-3. M-110 also inhibits the proliferation of 22Rv1, PC3, and SW480 cells, with IC50?values of 0.6 to 0.8 μM.Cell Viability Assay Cell Line:DU-145 cells Concentration:0.01, 0.1, 1, 10 μM Incubation Time:72 hours Result:Inhibiting the growth of DU-145 cells with an IC50?value of 0.9 μM.Western Blot Analysis Cell Line:DU-145 cells Concentration:10 μM Incubation Time:18 hours Result:Reduced the expression of p-STAT3 Tyr705?to 23.5%, compared with untreated cells without affecting the expression of STAT3.?
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In Vivo——
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SynonymsM110
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PathwayJAK/STAT Signaling
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TargetPim
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RecptorPim
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1395048-49-3
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Formula Weight445.9424
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Molecular FormulaC22H28ClN5O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(N/N=C(C1=CC=C(Cl)C=C1O)\CC)C2=CC=NC(NCCCN3CCOCC3)=C2
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Chemical Name4-Pyridinecarboxylic acid, 2-[[3-(4-morpholinyl)propyl]amino]-, 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chang M, et al. Mol Cancer Ther. 2010 Sep;9(9):2478-87.
2. Siu A, et al. Oncotarget. 2011 Dec;2(12):1134-44.
molnova catalog



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