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Luxdegalutamide

CAS No. 2750830-09-0

Luxdegalutamide( —— )

Catalog No. M36626 CAS No. 2750830-09-0

Luxdegalutamide (ARV-766) is a novel, potent, and orally bioavailable proteolytic targeting chimera (PROTAC) protein degrader that degrades not only wild-type AR but also clinically relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Luxdegalutamide
  • Note
    Research use only, not for human use.
  • Brief Description
    Luxdegalutamide (ARV-766) is a novel, potent, and orally bioavailable proteolytic targeting chimera (PROTAC) protein degrader that degrades not only wild-type AR but also clinically relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations.
  • Description
    Luxdegalutamide (ARV-766) is an orally active and potent proteolysis targeting chimera (PROTAC) protein degrader. Luxdegalutamide degrades wild-type androgen receptor (AR) but also relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PROTACs | Androgen Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2750830-09-0
  • Formula Weight
    807.95
  • Molecular Formula
    C45H54FN7O6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (123.77 mM; Ultrasonic )
  • SMILES
    O([C@H]1C(C)(C)[C@H](NC(=O)C2=CC=C(C=C2)N3CCC(CN4CCN(CC4)C5=CC(F)=C(C(N[C@@H]6C(=O)NC(=O)CC6)=O)C=C5)CC3)C1(C)C)C7=CC(OC)=C(C#N)C=C7
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Petrylak D P, et al. A phase 2 expansion study of ARV-766, a PROTAC androgen receptor (AR) degrader, in metastatic castration-resistant prostate cancer (mCRPC)[J]. 2023.
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