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Lucerastat

CAS No. 141206-42-0

Lucerastat ( N-Butyldeoxygalactonojirimycin;ACT-434964;OGT-923 )

Catalog No. M11715 CAS No. 141206-42-0

A galactose analogue that is an UDP-glucose ceramide glucosyltransferase (UGCG/GCS) inhibitor (IC50=41.4 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Lucerastat
  • Note
    Research use only, not for human use.
  • Brief Description
    A galactose analogue that is an UDP-glucose ceramide glucosyltransferase (UGCG/GCS) inhibitor (IC50=41.4 uM).
  • Description
    A galactose analogue that is an UDP-glucose ceramide glucosyltransferase (UGCG/GCS) inhibitor (IC50=41.4 uM); prevents glucosylceramide biosynthesis both in vitro and in mouse models of lysosome storage disorders, without affecting α-glucosidase I and II or β-glucocerebrosidase (IC50>1 mM); shows potential as substrate reduction therapy for glycolipid storage disorders such as Gaucher disease and Fabry disease.Other Indication Phase 1 Clinical
  • Synonyms
    N-Butyldeoxygalactonojirimycin;ACT-434964;OGT-923
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    141206-42-0
  • Formula Weight
    219.28
  • Molecular Formula
    C10H21NO4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O[C@H]1[C@@H](CO)N(CCCC)C[C@H](O)[C@H]1O
  • Chemical Name
    (2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Platt FM, et al. J Biol Chem. 1994 Oct 28;269(43):27108-14.
2. Andersson U, et al. Biochem Pharmacol. 2000 Apr 1;59(7):821-9.
3. Kasperzyk JL, et al. J Neurochem. 2004 May;89(3):645-53.
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