Loxiglumide ( CR-1505; Loxiglumide, brand name: Loxizin. )

Catalog No. M17793 CAS No. 107097-80-3

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Product Name

Loxiglumide
Note

Research use only, not for human use.
Brief Description

Loxiglumide is a cholecystokinin (CCK-1) receptor antagonist.
Description

Loxiglumide is a potent, orally active, and selective CCK-A receptor antagonist which stimulates calorie intake and hunger feelings in humans. Loxiglumide inhibits pancreatic secretion of digestive enzymes, and also blocks CCK-induced gastric secretions and emptying. Intravenous administration of loxiglumide antagonized the CCK-induced reduction of gastric emptying in rats, acceleration of intestinal transport in mice, increase in ileal motility in rabbits, gallbladder contraction in guinea pigs and acceleration of gallbladder emptying in mice.
Synonyms

CR-1505; Loxiglumide, brand name: Loxizin.
Pathway

Others
Target

Other Targets
Recptor

CCK
Research Area

——
Indication

——

CAS Number

107097-80-3
Formula Weight

461.38
Molecular Formula

C21H30Cl2N2O5
Purity

98%
Solubility

DMSO : ≥ 150 mg/mL; 325.11 mM
SMILES

CCCCCN(CCCOC)C(=O)C(CCC(=O)O)NC(=O)c1cc(c(cc1)Cl)Cl
Chemical Name

4-(3,4-dichlorobenzamido)-5-((3-methoxypropyl)(pentyl)amino)-5-oxopentanoic acid

1. Teyssen S, et al. Pancreas. 1996 Nov;13(4):407-16.2. Shiratori K, et al. Pancreas. 2002 Jul;25(1):e1-5.

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